BRNB Antibody (IHC)

BRAF is a serine/threonine kinase that participates in cell proliferation through formation of heterologous or homologous dimer activation. High expression of BRAF can be seen in neural tissue, melanocytes, and cells in testis and hematopoietic tissue. BRAF mutations are mostly located at codon 600. The original valine is replaced by glutamic acid, usually labeled BRAF V600E. This substitution leads to the activation of the MERK/ERK pathway, thereby promoting cell proliferation. BRAF mutations are common in benign and malignant tumors. BRAF V600E mutations are found in melanoma, papillary thyroid carcinoma, pleomorphic xanthoastrocytoma, Langerhans cell histiocytosis, borderline ovarian tumors, gliomas, colon cancer, and pilocytic astrocytes Cytoma. Currently it is mostly used in the research of tumors and targeted drugs.