MSH6 Antibody (IHC)

MSH6 is a mismatch repair gene located at position 16 of the P arm of chromosome 2. DNA mismatch repair is necessary to maintain the integrity of genetic information over time. Mutated mismatch repair proteins are often expressed in patients with high-frequency microsatellite instability (MSI-H) and are associated with autosomal dominant inheritance, also known as hereditary nonpolyposis colorectal cancer (HNPCC). Also seen in patients with sporadic (MSI-H) colorectal cancer. MLH1, MSH2, and MSH6 antibodies can be used to screen patients and their families for the disease. It has been reported in the literature that colorectal cancer patients with high frequency of microsatellite instability (MSI-H) have a better prognosis than patients with low frequency of microsatellite instability (MSI-L) and microsatellite stable (MSS).