TOP2A Antibody (IHC)

DNA topoisomerase can catalyze the breakage and combination of DNA strands, and insert into other DNA strands through transient gaps, thereby controlling the topological state of DNA. Topo II-α isoform is a nuclear protein with a molecular weight of 170kDa. It is designed to be expressed in proliferating cells and plays a crucial role in maintaining the spatial conformation of DNA and ensuring its function. Therefore, it has also become a candidate for some chemotherapy drugs (animal ring drugs). drug) sensitive target for attack.