HER2 Antibody (IHC)

C-erbB-2 is a transmembrane protein of tyrosine kinase receptor encoded by the HER2 gene, with a molecular weight of 185kDa. HER2 is a proto-oncogene, and its activation can directly lead to malignant transformation or increased malignant potential of some human cells. Many studies have shown that amplification of the HER2 gene leads to the occurrence of some breast cancer, gastrointestinal cancer, ovarian cancer, endometrial cancer and other tumors. At the same time, the amplified HER2 in these tumors is directly used as a targeted drug (such as Herceptin, etc.) drug) and used in the treatment of tumors. In recent years, a large number of research documents have shown that the expression of C-erbB-2 protein in tumor cell membranes is directly related to the amplification of the HER2 gene.