IgG4 Antibody (IHC)

IgG4 is a low-proportion IgG subtype, accounting for only 3% to 6% of the total IgG in normal human serum. IgG4-related sclerosing disease is a recently recognized syndrome characterized by tumor-like lesions in multiple organs, such as pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, and breast. , thyroid and prostate, etc., there is a large number of lymphocyte and plasma cell infiltration in the lesions, interstitial sclerosis, increased serum lgG4 titer, and increased lgG4+ plasma cells in the tissue. Patients can benefit from steroid therapy and have a good clinical prognosis, so in similar diseases The differential diagnosis of IgG4-related sclerosing diseases is very important. Immunohistochemical study results in cases of IgG4-related sclerosis found that IgG4 was significantly increased in the diseased tissue, and the IgG4/IgG ratio in the tissue was also significantly increased (>30%)